An intake interview is initially performed focusing on presenting symptoms and possible cause of PD such as penile trauma either through sexual activity or instrumentation. A family history of Dupuytren or Ledderhose disease, lupus or systemic fibrosis may be present. Vascular risk factors for ED including history of diabetes, hypertension, elevated cholesterol, hyperlipidemia may also establish possible risk factors.

Very important is a good history of erectile function. This includes, whether or not intromission is possible or not and if not is it because of the deformity or because of lack of rigidity.

A photograph taken at home of the erect penis from different angle may be useful to estimate the severity of the deformity.

Palpation and measurement of the stretched penis is performed to assess the extent and location of the plaque.

A penile Duplex ultrasonography is very useful. It allows for identification and measurement of the plaque. It also can identify penile fibrosis. It allows the doctor to observe the erectile response to a penile injection and to measure blood flow in and out of the penis and evaluate erect penile rigidity. It also enables the doctor to obtain measurement of the erect penis and deformity.