Now accepting Video or Phone Consultations. Schedule a virtual visit.

Non Surgical Options


 

Nonsurgical Treatment Options

Oral medications

  • Potaba
  • Vitamin E
  • Tamoxifen
  • Colchicine
  • Carnitine
  • Pentoxifylline
  • Phosphodiesterase Type 5 Inhibitors

Topical Drug Application

Electromotive Drug Administration

Extracorporeal Shockwave Therapy

 

Radiation therapy 

Vacuum therapy

Penile Traction

 

Injection of Plaque 

Verapamil

Nicardipine

Interferon

Clostridial Collagenase

 

Combination Therapy



Patients that have no pain or difficulty with intercourse may only require reassurance.  Currently no oral agent included in the list above has been shown in clinical trials to be better than placebo to result in clinically meaningful improvement of penile deformity and curvature. 

Similarly topical medication, shock wave and radiation therapy have not been shown to reduce penile deformity. Radiation could also increase the risk of ED. 

Vacuum therapy because of the short duration of the stretching forces on the penis does not benefit patients with PD.

Penile traction provides minimal improvement of penile curvature and penile length and for some patients, traction has been shown to be effective to recover lost length and reduce curvature if the device is applied to the penis for a minimum of 3 or more hours per day.

Studies of injection of the plaque with Verapamil have not shown any favorable response. A Nicardipine injection was shown to be effective in some patients in only one study published in 2010. A study comparing the injection of interferon vs. placebo showed a small benefit of interferon over saline injection, but the side effects and cost of interferon did not justify it’s use. Clostridial Collagenase (Xiaflex) is the first FDA approved injection drug for the treatment of PD. Initial studies have shown improvement of the symptoms of PD including reduction of the pain and 35% improvement of the curvature. Further experience will help to determine which patients will benefit the most from Xiaflex injections. A recent study did not demonstrate any benefit for patients with severe curvatures and in patients with ED. 

One study from 2012 using combination of daily pentoxifylline and L-arginine with Verapamil injections and penile traction showed the best result of correction of penile curvature, however the author did not specify how long traction was applied to the penis. More studies of combination therapy are needed to demonstrate efficacy. 

SURGICAL TREATMENT OPTIONS 

Location
Advanced Urological Care PC
435 East 63rd Street
Upper East Side

New York, NY 10065
Phone: 212-535-6690
Fax: 212-535-7025
Office Hours

Get in touch

212-535-6690